The acute effects of intravenous isosorbide dinitrate during cardiac surgery
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چکیده
منابع مشابه
Intravenous isosorbide dinitrate in patients with refractory pump failure and acute myocardial infarction.
We studied the hemodynamic effects of isosorbide dinitrate administered by continuous i.v. infusion to 22 patients with chronic refractory pump failure and 18 with pump failure due to acute myocardial infarction. In patients with severe pump failure, i.v. ISDN markedly decreased pulmonary capillary wedge pressure (p less than 0.001), moderately increased cardiac output (p less than 0.01), and d...
متن کاملHemodynamic effects of intravenous isosorbide dinitrate and nitroglycerine in acute myocardial infarction and elevated pulmonary artery wedge pressure.
We compared in a randomized fashion the hemodynamic effects of intravenous (IV) isosorbide dinitrate (ISDN) and nitroglycerine (NTG) in 45 patients with acute myocardial infarction and elevated pulmonary artery wedge pressure (Paw). Titration of ISDN dose to lower Paw greater than or equal to 25 percent resulted in a fall of this parameter from 32 +/- 8 to 24 +/- 5 mm Hg and was associated with...
متن کاملVasodilator properties of nitroglycerin and isosorbide dinitrate during cardiopulmonary bypass.
In a placebo-controlled trial, we have studied the vasodilator properties of bolus doses of nitroglycerin (TNG) and isosorbide dinitrate (ISDN) in 32 patients during cardiopulmonary bypass with a constant pump flow. Blood volume of the venous reservoir and mean arterial pressure were recorded for 10 min after drug administration to detect changes in venous capacitance and arteriolar resistance,...
متن کاملEnhancement by isosorbide dinitrate of haemodynamic effects of dopamine in chronic congestive cardiac failure.
The haemodynamic effects of dopamine and isosorbide dinitrate alone and in combination were studied in 8 patients with chronic congestive cardiac failure. In 7 patients dopamine, 6,tg/kg per min, increased mean cardiac index from 2-0 to 3 0 1/min per m2 (P < 0.0005); mean stroke volume index from 20 to 27 ml/m2 (P < 0.0025), and mean left ventricular stroke work index from 14 to 20 g M/M2 (P < ...
متن کاملClinical and circulatory effects of isosorbide dinitrate. Comparison with nitroglycerin.
In order to resolve current controversies on isosorbide dinitrate (ISDN), we employed a particularly sensitive testing protocol to evaluate effects of sublingual ISDN and nitroglycerin on the exercise capacity of patients with angina. Ten minutes after ISDN 21 of 23 patients exercised longer (average 2.7 minutes, P < 0.001) than after placebo. Benefit was evident in only a minority of patients ...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1987
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1987.tb04041.x